Process for preparing doxorubicin

Details Process for preparing doxorubicin Process for preparing doxorubicin

C - Chemistry, Metallurgy

12

N

C12N 15/76 (2006.01) C12N 1/21 (2006.01) C12N 15/52 (2006.01) C12P 19/56 (2006.01)

Patent

CA 2256318

The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.

La présente invention concerne un procédé permettant d'améliorer les processus d'obtention de daunorubicine et de doxorubicine au moyen d'un micro-organisme dans lequel un gène du métabolisme de la daunorubicine a subi une mutation. Le gène mutant est de préférence un dnrU et/ou dnrX.

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