Process for preparing doxorubicin

Details Process for preparing doxorubicin Process for preparing doxorubicin

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C12N 9/02 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01) C12N 15/76 (2006.01) C12P 19/56 (2006.01)

Patent

CA 2326500

The ability to convert daunorubicin into doxorubicin can be improved by transforming a host cell with a recombinant vector comprising a DNA molecule comprising: a DNA region or fragment containing the gene doxA encoding daunorubicin 14-hydroxylase and a DNA region or fragment containing one or more gene conferring daunorubicin and doxorubicin resistance.

On peut améliorer la capacité de conversion de la daunorubicine en doxorubicine en transformant une cellule hôte avec un vecteur recombinant comprenant une molécule d'ADN présentant une région ou un fragment d'ADN ou contenant le gène doxA codant pour la daunorubicine 14-hydroxylase et une région ou un fragment d'ADN contenant un ou plusieurs gènes conférant une résistance à la daunorubicine et à la doxorubicine.

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