Process for preparing enantiomer-enriched...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/42 (2006.01) C12N 1/00 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2541864

The present invention describes an enzymatic process for preparing enantiomer- enriched .alpha.-hydroxycarboxylic acids and amides which comprises, in one step, the conversion of a carbonyl compound to the corresponding acid/amides via the intermediate stage of a cyanohydrin. The invention also provides a reaction system operating in such a way and a whole-cell catalyst that is advantageous for use for this reaction.

L'invention concerne un procédé enzymatique pour la préparation d'acides .alpha.-hydroxycarboxyliques et d'amides enrichis en énantiomères, qui comporte la transformation, en une étape, d'un composé carbonyle en acides/amides correspondants, avec une étape intermédiaire au cours de laquelle de la cyanohydrine est formée. L'invention concerne aussi un système réactionnel mettant en oeuvre le procédé, et un catalyseur à cellules entières s'utilisant avantageusement dans cette réaction.

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