Process for preparing ethers of bufadienolide and...

C - Chemistry – Metallurgy – 07 – J

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C07J 19/00 (2006.01) C07J 41/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1107720

ABSTRACT OF THE DISCLOSURE The present invention provides the compounds of the present invention show an increased activity on the heart, in which connection the oral resorption is especially improved. It should be particularly noted, that the activity firstly increases with increasing chain length of the alkyl ether and then remains constant although the toxicity becomes lower. The compounds also have an especially good tolerance in the stomach and a slightly sedative action, which latter may be a desired side action in case of cardiac diseases. The new compounds can be administered in a form usual for heart glycosides, e.g. in form of tablets, capsules or solutions containing the active substance in pure form or in mixture with xanthine derivatives.

304930

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