Process for preparing fine particle pharmaceutical formulations

Details Process for preparing fine particle pharmaceutical formulations Process for preparing fine particle pharmaceutical formulations

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2182282

A process for preparing fine particle pharmaceutical formulations having improved throughput and producing greater uniformity of particle size comprises adding to the dry components of the formulation prior to the steps of wetting, extrusion and spheronization, an extrusion aid material selected from pharmaceutically acceptable oils and waxes having a drop point between about 15 °C and 115 °C.

L'invention concerne un mode de préparation de formulations pharmaceutiques à fines particules, caractérisées par un meilleur débit; pour produire des particules plus uniformes, on ajoute aux composants secs de la formulation, avant les étapes d'humectage, d'extrusion et de sphéroïdisation, un agent facilitant l'extrusion, choisi parmi des huiles et des cires acceptables du point de vue pharmaceutique et ayant un point de goutte entre 15 ~C et 115 ~C environ.

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