Process for preparing flumequine

Details Process for preparing flumequine Process for preparing flumequine

C - Chemistry, Metallurgy

07

D

260/271.5, 260/2

C07D 215/18 (2006.01) C07D 215/233 (2006.01) C07D 455/04 (2006.01)

Patent

CA 1159832

Abstract of the Disclosure An improved process for preparing the antimicrobial compound flumequine is disclosed. The first step of the process comprises reacting 4-fluoroaniline with crotonaldehyde under acidic conditions at a temperature between 50 and 60°C. In the second step, the product of the first step is slowly added to a refluxing solvent which forms a binary azeotrope with water and has a boiling point between 90° and 120°C to provide a mixture of 6-fluoroquinaldine and 6-fluorotetrahydroquinaldine. This mixture is then treated with base in the presence of weak acid followed by reducing to provide 6-fluorotetrahydroquinaldine. This compound is then treated according to known procedures to form flumequine.

369802

Affiliated with

Also associated with

Rating

Process for preparing flumequine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing flumequine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing flumequine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-541810