Process for preparing gemcitabine and associated intermediates

Details Process for preparing gemcitabine and associated intermediates Process for preparing gemcitabine and associated intermediates

C - Chemistry, Metallurgy

07

D

C07D 317/30 (2006.01) C07B 57/00 (2006.01) C07D 307/33 (2006.01) C07H 19/073 (2006.01)

Patent

CA 2641719

The present invention provides processes for preparing novel chemical substances that are useful as intermediates in the preparation of gemcitabine and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo (3R- and 3S-) isomers of 3-(hydroxy)- 2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionic acid salts. Also provided is a novel process for selectively isolating the D-erythro and D-threo isomers of the said salts in purities of at least about 95%, and processes of using them for preparing nucleoside analogs such as, e.g., gemcitabine and intermediates and analogs thereof.

La présente invention concerne de nouveaux procédés destinés à préparer de nouvelles substances chimiques utiles comme produits intermédiaires dans la préparation de gemcitabine ainsi que des procédés de préparation de gemcitabine au moyen de celles-ci. Des produits intermédiaires donnés à titre d'exemple comprennent des mélanges d'isomères D-érythro et D-thréo (3R- et 3S-) de sels d'acide 3-(hydroxy)-2,2-difluoro-3-(2,2-diméthyldioxolan-4-yl)propionique. L'invention concerne également un nouveau procédé pour l'isolement sélectif d'isomères D-érythro et D-thréo de ces sels en puretés d'au moins environ 95%, ainsi que leurs procédés d'utilisation pour préparer des analogues nucléosidiques tels que, par exemple, de la gemcitabine ainsi que des produits intermédiaires et des analogues correspondants.

Affiliated with

Also associated with

Rating

Process for preparing gemcitabine and associated intermediates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing gemcitabine and associated intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing gemcitabine and associated intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1767561