Process for preparing glyoxylic acid/dialkyl...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/40 (2006.01) C07F 9/38 (2006.01) C12P 13/04 (2006.01)

Patent

CA 2163515

The invention provides a process for producing mixtures of glyoxylate and a dialkyl aminomethylphosphonate and the subsequent production of N-(phosphonomethyl)glycine, also known as glyphosate. The process comprises preparing in situ a mixture of glyoxylate and a dialkyl aminomethylphosphonate (DEAMPA) by enzymatically reacting glycolic acid (glycolate) and oxygen in an aqueous solution in the presence of a dialkyl aminomethylphosphonate and catalysts consisting of glycolate oxidase and catalase. The resulting mixture can be hydrogenated and then subjected to hydrolysis to produce N-(phosphonomethyl)glycine, a post-emergent phytotoxicant and herbicide.

L'invention se rapporte à un procédé de production de mélanges de glyoxylate et d'un aminométhylphosphonate de dialkyle, et à la production ultérieure de N-(phosphonométhyl)glycine, également appelée glyphosate. Le procédé consiste à préparer in situ un mélange de glyoxylate et d'aminométhylphosphonate de dialkyle (DEAMPA) par la mise en réaction enzymatique d'acide glycolique (glycolate) et d'oxygène dans une solution aqueuse en présence d'un aminométhylphosphonate de dialkyle, et de catalyseurs composés de glycolate-oxydase et catalase. Le mélange obtenu peut être hydrogéné puis hydrolysé afin de produire N-(phosphonométhyl)glycine, un poison végétal et un herbicide de postlevée.

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