Process for preparing guanidinothiazole compounds

Details Process for preparing guanidinothiazole compounds Process for preparing guanidinothiazole compounds

C - Chemistry, Metallurgy

07

D

260/310.5

C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 277/48 (2006.01)

Patent

CA 1145345

ABSTRACT OF THE DISCLOSURE Novel guaniainothiazole compounds of the general formula Image wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1 - 3, A represents the group shown by Image or -CONH-R3 (wherein R1 represents a hydrogen atom, a cyano group, a carbamoyl group, an ureido group, a hydroxyl group, a lower alkoxy group, a lower acyl group, an acylamino group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group or a lower acyl group, and R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group or a sulfamoyl group), and the pharmacologically acceptable acid addition salts thereof, they are useful as gastric acid secretion inhibitors.

346986

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