Process for preparing hepatitis a (hav) antigens and vaccines

Details Process for preparing hepatitis a (hav) antigens and vaccines Process for preparing hepatitis a (hav) antigens and vaccines

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/29 (2006.01) C07K 14/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2108292

Process for preparing hepatitis A (HAV) antigens and vaccines. The HAV virus is multiplied on competent cells, the infected cells are lysed, the supernatant is recovered and the purification is carried out by a chromatographic procedure on an anion-exchange support and a gel filtration procedure, the purification procedures being carried out in the presence of a detergent, and the chromatographic procedure being carried out under conditions which retain the virions or viral capsids, which are then eluted.

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