C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/140, 260/219
C12P 19/26 (2006.01) A61K 35/00 (2006.01) C08B 37/00 (2006.01) C08B 37/08 (2006.01) C08B 37/10 (2006.01) C12P 19/00 (2006.01) C12P 19/04 (2006.01) C12P 19/44 (2006.01)
Patent
CA 1334516
A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in mucopolysaccha- rides (MPS), comprising the following essential stages: a) stabilising the fresh organs by freezing them either as such or in the form of powder, b) micronising the stable material containing the MPS with an aqueous CaC12 solution, c) digesting the homogenate comprising the raw material and the CaCl2 with proteolytic enzymes at alkaline pH and at low temperature, d) acidifying, heating and filtering the lysate, e) treating the filtrate with quaternary ammonium salts able to undergo complexing with and thus precipitate either the DS alone or all the MPS selectively, f) recovering and purifying the DS from the ammonium complex which contains it.
532821
de Ambrosi Luigi
Del Bono Rinaldo
Ferrari Gianni
Pagella Pier Giuseppe
Rugarli Pier Luigi
de Ambrosi Luigi
Del Bono Rinaldo
Ferrari Gianni
Marks & Clerk
Mediolanum Farmaceutici S.p.a.
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