Process for preparing hmg-coa reductase inhibitors with a...

Details Process for preparing hmg-coa reductase inhibitors with a... Process for preparing hmg-coa reductase inhibitors with a...

C - Chemistry, Metallurgy

07

C

260/477, 260/479

C07C 69/66 (2006.01) C07C 67/31 (2006.01) C07C 69/732 (2006.01)

Patent

CA 1282425

TITLE OF THE INVENTION PROCESS FOR PREPARING HMG-CoA REDUCTASE INHIBITORS WITH A 3,5-DIHYDROXYPENTANOATE SUBUNIT. ABSTRACT OF THE INVENTION A stereoselective process for the preparation of antihypercholesterolemic agents of the HMG-CoA reductase inhibitor type comprises treatment of an intermediate .beta.-hydroxyketone with a trialkylborane and sodium borohydride at low temperatures.

482598

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