Process for preparing hydrogels as spherical beads of large...

C - Chemistry – Metallurgy – 08 – F

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402/1, 400/5038

C08F 283/00 (2006.01) C08F 2/18 (2006.01) C08F 220/28 (2006.01) C08F 290/06 (2006.01) C08F 291/00 (2006.01)

Patent

CA 1136317

ABSTRACT OF THE DISCLOSURE The disclosure describes an improved process for the preparation of uniform, spherical beads of up to 5 mm diameter of a crosslinked, water-insoluble hydrogel by suspension polymerization in a concentrated aqueous salt solution of 95-30% by weight of a monoolefinic water- soluble monomer containing at least 5% of a hydroxy sub- stituted hydrophilic vinyl monomer with 5-70% by weight of a terminal diolefinic macromer crosslinking agent in the presence of water-insoluble, gelatinous, strong water-bonding inorganic metal hydroxides as suspending agents in the ab- sence of excess alkali. The hydrogels have a host of pharmaceutical and industrial uses.

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