Process for preparing hydroxyflavan compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 311/60 (2006.01) C07D 311/96 (2006.01)

Patent

CA 2151794

A process for preparing a hydroxyflavan compound which comprises reacting a polyhydric phenol compound represented by formula (2): Image (2) wherein at least one of W, X, Y and Z is hydroxy; with a ketone in the presence of (i) an acid catalyst and (ii) water and/or a seed crystal, using an organic solvent which is insoluble in water, procuces the hydroxyflavan compounds in high yield and with high selectivity while maintaining high conversion of the polyhydric phenol.

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