Process for preparing hypolipidaemiant products

C - Chemistry – Metallurgy – 07 – C

Patent

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260/385, 260/471

C07C 59/90 (2006.01) C07C 69/95 (2006.01) C07C 97/10 (1980.01)

Patent

CA 1072110

Abstract This invention provides a method of preparing a compound of the formula: Image (II) in which A is a methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or cyclohexyl group or a group of formula Image Image or Image [where each of Xl, X2 and X3 , which are identical or different is H, C1, Br, F, CF3, N02, NH2, OH, C1-4 alkyl, C1-4 alkoxy, benzyloxy, acetamido, acetoxy, CHO, COOH, a radical Image where Y is OH or C1-4 alkoxy; X6 is O or S; and X7 is H, Cl or Br]; each of R, X4 and X5, which are identical or different, is hydrogen or C1-4 alkyl; Y is H, OH, OM (where M is a metal- lic residue), C1-12 alkoxy, in which the chain is straight or branched, C3-8 cycloalkyloxy, Cl-4 alkylthio, 2,3- dihydroxypropyloxy, 4-12,2-dimethyl-1,3-dioxolannyl)- methylencoxy, which has the formula Image phenoxy, substituted phenoxy, 3-pyridylmethyleneoxy, 5-(2- methyl-3-hydroxy-4-hydroxymethylpyridyl)-methyleneoxy, which has the formula: Image a NZlZ2, NHCH2CH2NZlZ2, OCH2CH2NZlZ2 or O(CH2)mCONZ1Z2 group (where m is an integer from 1 to 4 and Zl and Z2 are Cl-4 alkyl groups, or Zl and Z2 together with the nitrogen atom to which they are joined may form a 5- to 7-membered N- heterocyclic group which may contain a second heteroatom such as O and N and may be substituted), or a group Image R' represents hydrogen, a Cl-C4 alkyl group or an acetyl group; and their addition salts comprising a compound of formula Image where A, X4, X5, R and Y are as defined above with an organic reducing agent and if necessary substituting the product to etherification or acetylation.

310733

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