Process for preparing ibuprofen and its alkyl esters

Details Process for preparing ibuprofen and its alkyl esters Process for preparing ibuprofen and its alkyl esters

C - Chemistry, Metallurgy

07

C

260/478.7, 260/5

C07C 51/10 (2006.01) C07C 57/30 (2006.01) C07C 67/36 (2006.01) C07C 69/612 (2006.01)

Patent

CA 2031340

PROCESS FOR PREPARING IBUPROFEN AND ITS ALKYL ESTERS Abstract of the Disclosure A new process for preparing ibuprofen or its alkyl esters is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted with carbon monoxide in the presence of water or an alcohol at a temperature between 10°C and 200°C. An excess of several moles of water or alcohol is preferred. An acid such as hydrochloric acid may also be added. As catalyst, a palladium compound and at least one acid-stable ligand are present; and an excess of ligand over palladium is advantageous.

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