Process for preparing imidazole derivative

Details Process for preparing imidazole derivative Process for preparing imidazole derivative

C - Chemistry, Metallurgy

07

D

260/314

C07D 233/61 (2006.01) B01J 31/02 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01)

Patent

CA 1154023

Abstract of the Disclosure The present invention relates to a novel process for preparing 4-[(2-aminoethyl)thiomethyl]-5-methyl imidazole of the formula Image I and its acid addition salts, characterized as a process for preparing 4-[(2-aminoethyl)thiomethyl]-5-methyl imidazole of the formula Image and its acid addition salts, characterized in that a compound of the formula Image wherein M represents hydrogen or an alkali metal, is reacted with a 2-haloethylamine, wherein halo represents chloro or bromo, in a system consisting of an aqueous solution or a strong base and of an organic phase, at room temperature in the presence of quaternary ammonium or quaternary phosphonium salts as phase transfer catalysts.

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