Process for preparing insulin compounds

Details Process for preparing insulin compounds Process for preparing insulin compounds

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) C07K 14/62 (2006.01)

Patent

CA 2464616

A preferred way of converting insulin precursors into insulin compounds is to perform an enzymatic peptide cleavage in an aqueous medium and, thereafter, without removal of the intermediate product formed, to add an amino acid ester or a peptide ester and an organic solvent so that the desired coupling takes place.

La présente invention concerne un procédé de conversion de précurseurs insuliniques en composés insuliniques. Pour un mode de réalisation préféré, on commence par un clivage enzymatique des peptides dans un milieu aqueux. Après élimination du produit intermédiaire formé, on ajoute un ester d'acide aminé ou un ester de peptide ainsi qu'un solvant organique de façon qu'intervienne le couplage attendu.

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