Process for preparing intermediates for the synthesis of...

Details Process for preparing intermediates for the synthesis of... Process for preparing intermediates for the synthesis of...

C - Chemistry, Metallurgy

12

P

C12P 7/62 (2006.01) C07C 69/63 (2006.01) C07C 69/65 (2006.01) C07D 263/26 (2006.01) C07D 307/12 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2161662

Disclosed is a process for preparing chiral compounds of formula (I) wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of formula (I) or (III) wherein: X1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2OR'; Q* represents a chiral auxiliary group; R" represents a hydroxy protecting group; and A represents Cl, Br, I, triazolyl or imidazolyl; are also disclosed.

Procédé de préparation de composés chiraux de formule (I). Dans la formule (I) X1 et X2 représentent indépendamment F ou Cl; et E représente -SO2R2, R2 représentant alkyle C1-C6, -C6H4CH3 ou -CF3. Ces composés chiraux, leur énantiomère et leurs racémates sont utiles dans la synthèse d'agents antifongiques au tétrahydrofurane azole. Cette invention concerne également de nouveaux composés de formules (II) ou (III). Dans la formule (II), X1 et X2 représentent indépendamment F ou Cl; B représente -C(O)Q* ou -CH2OR"; Q* représente un groupe auxiliaire chiral; R" représente un groupe protecteur hydroxy; et A représente Cl, B, I, triazolyle ou imidazolyle.

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