Process for preparing isoureas and isothioureas

Details Process for preparing isoureas and isothioureas Process for preparing isoureas and isothioureas

C - Chemistry, Metallurgy

07

D

260/255

C07D 239/47 (2006.01) C07D 239/46 (2006.01) C07D 403/02 (2006.01)

Patent

CA 1114375

ABSTRACT Pyrimidine compounds which are histamine H2- antagonists and also have histamine H1-antagonist activity and antiinflammatory activity having the structure Image in which R1 and R2 are hydrogen, lower alkyl, or together with the carbon and two nitrogen atoms shown form a dihydroimidazolyl or tetrahydropyrimidyl group, Y is sulphur or oxygen, n is from 3 to 8, X is oxygen or sulphur, Z is hydrogen or lower alkyl, A is C1-C5 alkylene or -(CH2)pW(CH2)q- where W is oxygen or sulphur and the sum of p and q is 1 to 4, and B is methyl, cycloalkyl, heteroaryl, aryl or, when A is alkylene, hydrogen, are prepared by a process in which a compound of structure Image where D is HY- or a leaving group is reacted with: (a) when D is HY-, an isothiourea Image where A is lower alkyl or aryl(lower alkyl), or a cyanamide R1HNCN or a carbodiimide R1N=C=NR2 or (b) when D is a leaving group, a urea or thiourea Image or, when Y is oxygen a compound of structure Image where G is a lower alkylthio, chlorine, bromine or NO2NH-, is reacted with an isothiourea of Structure Image

331756

Affiliated with

Also associated with

Rating

Process for preparing isoureas and isothioureas does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing isoureas and isothioureas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing isoureas and isothioureas will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-377665