Process for preparing lankacidine carbamate derivatives

C - Chemistry – Metallurgy – 07 – D

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260/266.1, 260/3

C07D 313/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2021881

A process for preparing a lankacidine carbamate derivative of the formula (see above formula) or a salt thereof, by the reaction of a lankacidine 8-substituted carbonate with an amine, wherein R1 is a hydroxy group or an alkanoyloxy group; and R2 and R3 are each a hydrogen atom, an optionally substituted lower alkyl group, a cycloalkyl group or a phenyl group; or R2 and R3 together with an adjacent nitrogen atom to which they bond form an optionally substituted heterocyclic group. The product is useful as anti-microbial agent.

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