Process for preparing linezolid

Details Process for preparing linezolid Process for preparing linezolid

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) C07C 251/06 (2006.01)

Patent

CA 2648178

The present invention relates to a new process for preparing the oxazolidinone antibacterial agent linezolid which comprises the reaction of an (S)-I -chloro-3- (benzyIidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield.

La présente invention concerne un nouveau procédé de préparation du linézolide, un agent antibactérien oxazolidinone, ledit procédé impliquant de faire réagir un (S)-I-chloro-3- (benzylidénylamino)propan-2-ol avec un morpholinyle fluorophényle carbamate afin d'obtenir un intermédiaire imine protégé, lequel conduit par hydrolyse et acylation au linézolide, avec un rendement élevé.

Affiliated with

Also associated with

Rating

Process for preparing linezolid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing linezolid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing linezolid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1561409