Process for preparing macrocyclic compounds

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/078 (2006.01) B01J 31/22 (2006.01) C07B 37/10 (2006.01) C07D 207/10 (2006.01) C07D 265/32 (2006.01) C07K 1/00 (2006.01) C07K 1/08 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2522205

Disclosed is a process for preparing a macrocyclic compound of the formula (I) which is carried out using an intermediate of the formula (II) wherein W, R1 through R4, D,A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

La présente invention se rapporte à un procédé de préparation d'un composé macrocyclique représenté par la formule (I) qui est mis en oeuvre au moyen d'un intermédiaire représenté par la formule (II). Dans les formules (I) et (II), W, R?1¿ à R?4¿, D, A et R?12¿ sont définis dans la description. Les composés représentés par la formule (I) sont de puissants agents actifs pour le traitement de l'infection par le virus de l'hépatite C (HCV).

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