Process for preparing major histocompatibility antigen class...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61M 1/34 (2006.01) B01D 15/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C07K 17/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2125871

-24- ABSTRACT This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as "MHC class II" for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials in which MHC class II, .alpha. and/or .beta. subunit of MHC class II, or a part thereof is bound to a carrier such as beads, fibers and hollow fibers via covalent bond, as well as a module for removing superantigen using the same. This invention also provides a method for detecting or quantifying superantigens using MHC class II or a part thereof having an affinity to the superantigens, as well as an assay kit therefor.

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