Process for preparing maytansinoid antibody conjugates

Details Process for preparing maytansinoid antibody conjugates Process for preparing maytansinoid antibody conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2620343

The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell- binding agent and a subsequent purification step.

L'invention concerne un procédé de préparation d'un agent de liaison cellulaire chimiquement couplé à un médicament. Le procédé fait appel à la fixation de manière covalente d'un lieur à un agent de liaison cellulaire, à une étape de purification, à la conjugaison d'un médicament à l'agent de liaison cellulaire et à une étape de purification ultérieure.

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