C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01)
Patent
CA 2383829
A process for the preparation of salts of substituted or unsubstituted methylene bisphosphonic acids by hydrolysing the corresponding acid ester with hydrochloric acid, removing water from the acid azeotropically prior to addition of an amine or a base to produce the resultant salt in good yield.
L'invention concerne un procédé de préparation de sels d'acides méthylènebisphosphoniques substitués ou non-substitués, consistant à hydrolyser l'ester d'acide correspondant avec de l'acide chlorhydrique; à retirer, de manière azéotrope, l'eau contenue dans l'acide avant d'ajouter un amine ou une base afin de produire ledit sel avec un bon rendement.
Astrazeneca Uk Limited
Fetherstonhaugh & Co.
LandOfFree
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