C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 303/40 (2006.01) C07C 269/06 (2006.01) C07C 271/18 (2006.01) C07D 301/26 (2006.01) C07D 303/36 (2006.01)
Patent
CA 2163062
The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
La présente invention porte sur une nouvelle méthode utile pour la conversion d'aminoacides en halométhylcétones, qui sont ensuite converties en époxydes d'aminoacides. Ces époxydes sont d'importants intermédiaires pour la synthèse de la rénine et de la protéase de VIH, qui sont particulièrement utiles pour le traitement et (ou) la prévention de l'infection par le VIH (SIDA).
Barrish Joel C.
Chen Ping
Cheng Peter Tai Wah
Polniaszek Richard P.
Spergel Steven H.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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