Process for preparing naproxen

Details Process for preparing naproxen Process for preparing naproxen

C - Chemistry, Metallurgy

07

C

260/508.5

C07C 59/66 (2006.01) C07C 45/46 (2006.01) C07C 49/84 (2006.01) C07C 51/00 (2006.01)

Patent

CA 1238341

ABSTRACT OF THE DISCLOSURE This invention discloses a novel and efficient process for preparing 6-methoxy- ? -methyl-2- naphthaleneacetic acid (hereinafter Naproxen), via a sequence of sterospectic reactions. The process comprises condensing 1-chloro-2-methoxy-naphthalene with a (s)-2-halo- propionyl halide according to the Friedel-Crafts reaction, ketalization of the thus produced (s)-2-halo-1-(5'-chloro- 6'-methoxy-2'-naphthyl)- propan-1-one, rearrangement of the ketal to form an ester, hydrolysis of the ester and removal of the the chlorine atom in the 5-position by hydrogenolysis.

481094

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