Process for preparing nebivolol

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 407/12 (2006.01) C07D 317/20 (2006.01) C07D 317/22 (2006.01) C07D 407/04 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2667919

The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer /-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-l,3 dioxolane-4- carbaldehyde and a vinyl Grignard reagent.

La présente invention concerne un procédé de préparation de nébivolol et plus particulièrement un procédé de préparation de d-nébivolol et de son énantiomère l-nébivolol ou de sels d'addition acide de ceux-ci à partir de 2,2-diméthyl-1,3 dioxolane-4-carbaldéhyde disponible dans le commerce ou facile à obtenir et d'un réactif de Grignard vinylique.

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