Process for preparing nebivolol

Details Process for preparing nebivolol Process for preparing nebivolol

C - Chemistry, Metallurgy

07

D

C07D 407/04 (2006.01) C07D 311/22 (2006.01) C07D 311/58 (2006.01) C07D 407/12 (2006.01)

Patent

CA 2668436

The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.

La présente invention porte sur un procédé de fabrication de Nébivolol et, plus particulièrement, sur un procédé perfectionné pour synthétiser des dérivés 6-fluoro chromane alcool ou époxyde énantiomériquement enrichis de formule, dans laquelle R et X sont définis dans la description, comme intermédiaires utiles dans la préparation de Nébivolol.

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