C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) C07D 407/04 (2006.01)
Patent
CA 2714051
The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/ SR configuration characterized in that said reduction is carried out by the use of (+)- B- chlorodiisopinocampheylborane or (-)- B- chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
La présente invention porte sur un procédé de préparation du Nebivolol et, plus particulièrement, sur un procédé permettant la réduction stéréosélective d'une alpha-halocétone de formule (I) : intermédiaire utile pour la préparation du Nebivolol.
Cotarca Livius
Foletto Johnny
Maragni Paolo
Massaccesi Franco
Munari Ilaria
Riches Mckenzie & Herbert Llp
Zach System S.p.a.
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