Process for preparing netilmicin

Details Process for preparing netilmicin Process for preparing netilmicin

C - Chemistry, Metallurgy

07

H

260/210, 260/230

C07H 15/236 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1290751

ABSTRACT A high yielding process ofr converting 3,2',6'- tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5, 2" positions, and optionally at the 4" positon, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, deprotecting the compound and recovering netilmicin. Also disclosed are novel intermediate compounds.

520424

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