Process for preparing new antibiotic derivatives

Details Process for preparing new antibiotic derivatives Process for preparing new antibiotic derivatives

C - Chemistry, Metallurgy

07

H

260/230.37

C07H 17/08 (2006.01)

Patent

CA 1053665

ABSTRACT OF THE DISCLOSURE Novel derivatives of midecamycine, of the formula: Image (I) wherein X represents an oxygen atom or a sulphur atom, R1 represents a straight or branched lower alkyl group, a lower alkenyl group or a phenyl group, R2 represents a hydrogen atom or a lower carboxylic acid acyl group, the dotted lines represent the possible presence of double bonds, it being understood that the 2 double bonds at the 10,11 position on the one hand and the 12,13 position on the other either exist simultaneously or neither of them exists, which give by oral administration plasma rates which are higher than midecamycine and which lack its bitter taste, together with their process of preparation.

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