Process for preparing new n.sub.1-acyl-3-amino-1,2,3,...

Details Process for preparing new n.sub.1-acyl-3-amino-1,2,3,... Process for preparing new n.sub.1-acyl-3-amino-1,2,3,...

C - Chemistry, Metallurgy

07

D

260/284, 260/277

C07D 215/38 (2006.01) C07D 401/06 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1195331

ABSTRACT OF THE DISCLOSURE This invention relates to new tetrahydroquin- oline compounds of the general formula (I): Image (I) wherein R1 is selected from the group comprising a straight or branched chain alkyl having from 1 to 20 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, phenyl, phenyl substituted by halogen atom, phenyl C1-6 alkyl, phenyl C1-6 alkenyl, pyridyl, and pyridyl substituted by one or two halogen atoms; R2 and R3 are the same or different and each is selected from the group comprising hydrogen atom, hydroxy and alkoxy having from 1 to 6 carbon atoms, provided that at least one of R2 or R3 is different from hydrogen; R4, R5, R6 and R7 are the same or different and each is selected from the group comprising hydrogen atom and alkyl having from 1 to 6 carbon atoms; and pharmaceutically acceptable acid addition salts thereof. These compounds are prepared by a process which comprises reacting a compound of the general formula (II): Image (II) wherein R2, R3, R4, R5, R6 and R7 are defined herein- before, or a reactive derivative thereof, with a compound of the general formula R1-COOH or a reactive derivative thereof. These compounds and their salts are active on the cardiocirculatory system and are useful as cardiotonics.

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