Process for preparing new penem compounds

Details Process for preparing new penem compounds Process for preparing new penem compounds

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/88 (2006.01)

Patent

CA 1281713

ABSTRACT There is provided a process for preparing penems of the formula Image wherein R is hydrogen atom or C1-C4 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, A is Z, ZOCO or ZCO residue, wherein Z is phenylene, naphthylene, heterocyclediyl, C1-C7 alkylene, C2-C4 alkenylene, alkynylene, Image , C3-C8 cyclo- alkylene, aralkylene radical optionally substituted, and Q(+) represents a group Image , wherein R1, R2 and R3 are each either: (i) optionally substituted alkyl, aralkyl or aryl radical or (ii) R1 is as defined above under (i) and R2, R3, taken together, represent an optionally substituted or fused heterocyclic radical or (iii) R1, R2, R3, taken together, represent an optionally substituted azonia-bicyclo or tricyclo radical or (iv) R1, R2, R3, taken together, represent an optionally substituted or fused pyridinium, pyrazinium, pyrazolium or pyridazinium radical, and the pharmaceutically or veterinarily acceptable salts thereof. The compounds show high antibacterial activity.

506024

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