Process for preparing nitriloamides

Details Process for preparing nitriloamides Process for preparing nitriloamides

C - Chemistry, Metallurgy

12

P

195/86, 260/555.

C12P 13/02 (2006.01) C07C 237/06 (2006.01) C07C 255/24 (2006.01) C07C 255/29 (2006.01)

Patent

CA 2010929

A process for the selective preparation of nitrilo mono-, di- or tri- amides comprising the steps of: a) Forming in a slurry reactor a substrate comprising a saturated aqueous suspension of nitrilotrinitrile having the formula: (see formula I) wherein R1, R2 and R3 are independently selected from alkylene radical having 1-20 carbon atoms, b) farming in a bioreactor, free or immobilized whole cell microorganisms having high nitrile hydratase activity, c) circulating the substrate from (a) through a filter into the bioreactor from (b) wherein the substrate is hydrolyzed by the whole cells of (b) to farm a corresponding nitrilo mono-, di- or tri- amide product.

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