Process for preparing nitro compounds

Details Process for preparing nitro compounds Process for preparing nitro compounds

C - Chemistry, Metallurgy

07

D

260/300, 260/262

C07D 233/64 (2006.01) C07D 203/12 (2006.01) C07D 207/24 (2006.01) C07D 211/72 (2006.01) C07D 239/06 (2006.01) C07D 403/12 (2006.01)

Patent

CA 1118774

ABSTRACT This invention concerns compounds showing activity as histamine H2-receptor antagonists. The compounds of the invention are of Structure Image where Het is a substituted or unsubstituted, fully-unsaturated 5- or 6- membered heterocycle containing at least one nitrogen atom, or a furan or thiophene ring substituded by a substituted or unsubstituted aminoalkyl group; Z is sulphur, methylene or oxygen; m is 0, 1 or 2, 3 is 2 or 3 with m + n being 3 or 4; and B is a substituted or unsubstituted alkanediyl group or a 2-substituted-2-aza-l,3-propanediyl group and acid addition salts thereof. The compounds of he invention can be prepared by reacting a compound of formula Het (CH2)mZ(CH2)nNH2 or Het(CH2)mY (where Y is a group dis- placeable by a mercaptan) with an appropriate 2-substituted- 3-nitro-heterocycle. The compositions of the invention contain at least one compound of the inventicn and a pharma- ceutical carrier.

328543

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