C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.5
C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 471/04 (2006.01) A61K 31/495 (2006.01)
Patent
CA 1047495
ABSTRACT OF THE DISCLOSURE The present invention relates to the process for preparing 1-nitro- phenylpyrido [2,3-d]pyrimidine-2,4(1H,3H)-diones represented by the following formula: Image wherein R is selected from the group consisting of lower alkyl, substituted lower alkyl, unsaturated lower alkyl, substituted unsaturated lower alkyl and aralkyl. The compounds prepared according to the process of the present invention possess a high degree of pharmacological activities such as anti-inflamma- tory, anti-ulcerative, analgetic, antipyretic, antihistaminic and central nervous system depressive activities, and certain of them are useful as new anti-inflam-matory agents, analgesics and central nervous system depressants.
216601
Ide Hiroyuki
Motomura Toshiharu
Nakagawa Akira
Noda Kanji
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