Process for preparing novel n-substituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/20 (2006.01) A61K 31/505 (2006.01) C07D 239/22 (2006.01) C07D 239/28 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1289958

A PROCESS FOR PREPARING NOVEL N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE DERIVATIVES Abstract: A N-substituted 3,4-dihydropyrimidine derivative of the formula (1): Image (1) wherein R1 is -(CH2)n-X; X is substituted aminoethyl, substituted sulfide-ethyl, substituted or non-substituted heterocyclo-ethyl wherein the ethylene group is directly bonded to a hetero atom in the heterocyclic ring, or substituted or non-substituted heterocyclo-methyl wherein the methylene group is directly bonded to a carbon atom in the heterocyclic ring; n is an integer from 0 to 8; R2 is straight, branched, cyclic or cyclo-straight alkyl having from one to thirteen carbon atoms, or aralkyl having from seven to thirteen carbon atoms and pharmacologically acceptable acid addition salts thereof have substantially strong and long lasting effects. Therefore the compounds are useful as agents for treating disorders of the cardio- vascular system, for example, antihypertensive agent, circulation improver and antianginal agent. A process for producing the above compounds economi- cally and effectively is disclosed.

517393

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