Process for preparing nucleoside compound

Details Process for preparing nucleoside compound Process for preparing nucleoside compound

C - Chemistry, Metallurgy

12

P

C12P 19/38 (2006.01)

Patent

CA 2373189

A process for producing a nucleoside compound by reacting pentose-1-pohosphate with a nucleic acid base or a nucleic acid base analog in the presence of the enzymatic activity of nucleoside phosphorylase, wherein a metal salt capable of forming a hardly water-soluble salt with phosphoric acid is added to the reaction system so that the phosphoric acid formed as a by-product is removed from the reaction system and the equilibrium of the reaction shifts toward the synthesis of the nucleoside, which makes it possible to give the target nucleoside at a high yield.

L'invention concerne un procédé de production d'un composé nucléosidique, qui consiste à faire réagir du pentose-1-phosphate avec une base d'acide nucléique ou un analogue de base d'acide nucléique, en présence de l'activité enzymatique de phosphorylase nucléosidique, un sel métallique capable de former un sel difficilement soluble dans l'eau avec un acide phosphorique étant ajouté au système réactionnel, de sorte que l'acide phosphorique formé en tant que sous-produit soit enlevé dudit système réactionnel et que l'équilibre de la réaction soit décalé pour la synthèse du nucléoside, ce qui permet de produire le nucléoside cible en grande quantité.

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