Process for preparing o-acetylserine, l-cysteine and...

Details Process for preparing o-acetylserine, l-cysteine and... Process for preparing o-acetylserine, l-cysteine and...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12P 13/06 (2006.01) C12P 13/12 (2006.01)

Patent

CA 2235752

The invention concerns processes for preparing O-acetylserine, L-cysteine and sulphurous compounds derived therefrom using feedback-resistant serine acetyl transferases. In comparison with the wild-type enzyme, these serine acetyl transferases have reduced sensitivity to the inhibitor L-cysteine and a protein sequence which, in comparision with the wild-type enzyme, displays at least one mutation or deletion. The processes are characterized in that the mutation lies in the sequence region of the amino acid in position 97 up to and including the amino acid in position 273 or the deletion lies in the carboxy terminal sequence region as from the amino acid in position 227, position 1 being the starter methionine of figure (5) (SEQ ID NO: 1) and the mutation from Met to Ile in position 256 being excluded.

L'invention concerne des procédés de préparation de O-acétylsérine, L-cystéine et de composés contenant du soufre qui en sont dérivés, à l'aide de sérinacétyltransférases rétrorésistantes. Comparativement à l'enzyme de type sauvage, les sérinacétyltransférases présentent une sensibilité réduite vis-à-vis de la L-cystéine inhibitrice et une séquence protéique qui, comparativement à la séquence de type sauvage, présente au moins une mutation ou une délétion. Les procédés présentés se caractérisent en ce que la mutation intervient dans la zone séquentielle de l'aminoacide en position 97 jusqu'à et y compris l'aminoacide en position 273, ou la délétion intervient dans la zone séquentielle carboxy-terminale à partir de l'aminoacide en position 227, la position 1 constituant la méthionine de départ de la fig. 5 (SEQ ID NO:1) et la mutation de Met en Ile en position 256 étant exclue.

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