Process for preparing o-desmethylvenlafaxine

Details Process for preparing o-desmethylvenlafaxine Process for preparing o-desmethylvenlafaxine

C - Chemistry, Metallurgy

07

C

C07C 213/00 (2006.01) A61K 31/137 (2006.01) A61P 25/24 (2006.01) C07C 213/10 (2006.01) C07C 215/64 (2006.01)

Patent

CA 2703647

The present invention provides a convenient and efficient process for the preparation of 0-desmethylvenlafaxine (ODV), comprising the reaction of venlafaxine, or a salt thereof, with a thiol reagent such as a dithiol, an aminothiol or an inorganic thiol. The present invention also provides a process for purifying ODV base,said process comprising the steps of mixing crude ODV base with an alcohol to form a suspension and adding acid followed by base to generate ODV base with high purity.

La présente invention porte sur un procédé commode et efficace pour la préparation de O-desméthylvenlafaxine (ODV). Ce procédé consiste à faire entrer en réaction du venlafaxine ou un sel de celle-ci avec un réactif thiol tel qu'un dithiol, un aminothiol ou un thiol inorganique. La présente invention porte également sur un procédé de purification de ODV base qui consiste à mélanger de l'ODV base brute avec un alcool pour former une suspension et à ajouter un acide puis une base pour générer de l'ODV base de pureté élevée.

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