C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/56 (2006.01)
Patent
CA 2525862
Novel process to manufacture omega form and form-II of anhydrous Gatifloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-l~piperazinyl)-3- guinodine carboxylic acid) having structural formula (I) is disclosed. The invention does not require high temperature or use of column chromatography for purification. Moreover the solvents being used in the process can be recovered and recycled. These factors make the process industrially efficient.
La présente invention concerne un nouveau procédé pour fabriquer la forme oméga et la forme II de la Gatifloxacine (acide 1-cyclopropyl-6-fluoro-1,4-dihydro-8-méthoxy-7-(3-méthyl-1-pipérazinyl)-3-guinodine carboxylique) ayant la formule développée (I). Pour la purification, ce procédé n'exige pas de haute température ou l'utilisation de la chromatographie sur colonne. En outre, les solvants utilisés au cours du procédé peuvent être récupérés et recyclés. Ces facteurs rendent le procédé efficace au plan industriel.
Agarwal Virendra Kumar
Lakkad Mahendra Gordhanbhai
Naik Ashish Prafullchandra
Pandita Kanwal
Patel Pankaj Ramanbhai
Agarwal Virendra Kumar
Cadila Healthcare Limited
Lakkad Mahendra Gordhanbhai
Naik Ashish Prafullchandra
Pandita Kanwal
LandOfFree
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