Process for preparing optically active...

Details Process for preparing optically active... Process for preparing optically active...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12P 13/02 (2006.01)

Patent

CA 2354382

The invention relates to a new method for producing enantiomer-enriched 1-amino-4-(hydroxymethyl)cyclopent-2-ene derivatives of the general formulae (I) and (II) in which R1 is hydrogen or a possibly substituted C1-8-alkyl rest, aryl rest or cycloalkyl rest and R2 is a possibly substituted acyl. According to said method a racemic 1-amino-4- (hydroxymethyl)cyclopent-2-ene derivative of general formula (III), in which R1 has the meaning given above, is converted using a hydrolase and in the presence of an acylation agent.

L'invention a pour objet une nouvelle méthode de production de dérivés de 1-amino-4- (hydroxyméthyl)cyclopent-2-ène, enrichis en un énantiomère, de formules générales (I) et (II), dans lesquelles R1 représente un hydrogène ou un reste d'alkyle en C1-8, un reste d'aryle ou un reste de cycloalkyle éventuellement substitué, et R2 représente un acyle éventuellement substitué. Selon ladite méthode, un dérivé racémique de 1-amino-4-(hydroxyméthyl)-cyclopent-2-ène de formule générale (III), dans laquelle R1 a la signification susmentionnée, est converti au moyen d'une hydrolase et en présence d'un agent d'acylation.

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