Process for preparing optically active dihydropyrones

Details Process for preparing optically active dihydropyrones Process for preparing optically active dihydropyrones

C - Chemistry, Metallurgy

07

C

C07C 67/56 (2006.01) C07D 309/32 (2006.01) C07D 405/12 (2006.01) A61K 31/4433 (2006.01) A61P 31/18 (2006.01) C07C 69/72 (2006.01)

Patent

CA 2509157

The invention relates to a method for the production of optically aktive 5- Hydroxy-3-ketoesters of formula (A1) or (A2), or one of the tautomers thereof, the use thereof in the production of optically active dihydropyrones of formula (B), and the use of the thus produced dihydropyrones of formula (B) as starting compounds for the production of pharmaceutically active compounds, especially tipranavir.

La présente invention concerne un procédé pour préparer du 5-hydroxy-3-cétoester optiquement actif de formule (A1) ou (A2), ou l'un de ses tautomères, son utilisation pour la préparation de dihydropyrones optiquement actives de formule (B), et l'utilisation des dihydropyrones de formule (B) ainsi obtenues en tant que composés de départ pour la préparation de composés pharmaceutiquement actifs, en particulier du tipranavir.

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