Process for preparing optically active ¬s|-2-...

Details Process for preparing optically active ¬s|-2-... Process for preparing optically active ¬s|-2-...

C - Chemistry, Metallurgy

07

D

260/364

C07D 407/12 (2006.01) C07D 301/02 (2006.01) C07D 307/86 (2006.01)

Patent

CA 1190238

Abstract of the Disclosure [S]-(+)-2-acetyl-7-(2,3-epoxypropoxy)benzofuran (SEBF) is prepared by subjecting 2-acetyl-7-hydroxy- benzofuran and [R]-glycidol to dehydration condensation in an inert organic solvent in the presence of triphenylphosphine and a dialkyl azodicarboxylate. The [S]-(+)-2-acetyl-7-(2,3-epoxypropoxy)benzofuran can be easily converted into [S]-2-acetyl-7-(2-hydroxy-3-iso- propylaminopropoxy)benzofuran ([S]-befunolol) or salts thereof which are useful as a .beta.-adrenergic blocking agent, by reacting it with isopropylamine.

422900

Affiliated with

Also associated with

Rating

Process for preparing optically active ¬s|-2-... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing optically active ¬s|-2-..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing optically active ¬s|-2-... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1340153