Process for preparing oral calcium compositions

Details Process for preparing oral calcium compositions Process for preparing oral calcium compositions

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2349565

The invention provides a process for the preparation of an orally administrable calcium composition, said process comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40µm, having a crystalline structure and having a surface area of 0.1 to 1.2 m2/g; (ii) mixing said calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing said first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing said first or second granulate to form tablets.

L'invention concerne un procédé de préparation d'une composition à base de calcium administrée par voie orale, le procédé consistant en ce qui suit: (i) obtenir un composé particulaire physiologiquement tolérable à base de calcium qui possède un granulométrie moyenne entre 3 et 40 mu m, présente une structure cristalline et a une aire spécifique entre 0,1 et 1,2 m<2>/g; (ii) mélanger ce composé à base de calcium avec un liant hydrosoluble dans un appareil de granulation à lit fluidisé et sécher le mélange ainsi obtenu pour produire un premier granulat; (iii) éventuellement mélanger ce premier granulat avec un ou plusieurs autres composants pour produire un deuxième granulat; et (iv) éventuellement comprimer les premier et second granulats pour obtenir des comprimés.

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