Process for preparing penems

Details Process for preparing penems Process for preparing penems

C - Chemistry, Metallurgy

12

P

195/98

C12P 37/00 (2006.01) C07D 499/88 (2006.01)

Patent

CA 1300539

ABSTRACT "PROCESS FOR PREPARING PENEMS" Compounds of the formula I : Image (I) wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, useful as intermediates for the preparation of penem antibiotics, are prepared by hydrolysing a compound of the formula II : Image (II) wherein R1 and R2 are as defined above and R represents an alkyl, alkenyl or phenylalkyl group having from 1 to 18 carbon atoms, by means of an enzyme capable of selectively hydrolysing the ester group of the 2-substituent thereof.

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