C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/02 (2006.01) C07K 1/06 (2006.01) C07K 5/075 (2006.01)
Patent
CA 2227732
The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables peptides to be synthesized simply and economically and the protective group to be separated carefully. The process comprises three reaction steps: 1. preparation of N-carbamoyl amino acid or N-carbamoyl amino acid derivatives; 2. formation of the peptide bond between the carbamoyl-protected electrophile and nucleophile; and 3. separation of the carbamoyl-protective group.
L'invention concerne un procédé de production enzymatique d'oligopeptides et dipeptides protégés ainsi que la séparation des groupes de protection utilisés. Le procédé selon l'invention permet de réaliser facilement et à moindre frais une synthèse de peptides ainsi qu'une séparation douce du groupe de protection. Le procédé consiste en une réaction comportant les trois étapes suivantes: 1. préparation de l'acide aminé à protection N-carbamoyle ou du dérivé d'acide aminé à protection N-carbamoyle; 2. création d'une liaison peptidique entre un électrophile et un nucléophile à protection carbamoyle; et 3. séparation du groupe de protection carbamoyle.
Bommarius Andreas
Drauz Karlheinz
Eichhorn Uwe
Jakubke Hans-Dieter
Kottenhahn Matthias
Aktiengesellschaft Degussa
Marks & Clerk
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