Process for preparing pharmaceutical compositions for use...

Details Process for preparing pharmaceutical compositions for use... Process for preparing pharmaceutical compositions for use...

A - Human Necessities

61

K

A61K 31/192 (2006.01) A61K 9/48 (2006.01) A61K 31/167 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2419993

The invention disclosed herein is a process for increasing the achievable concentration of a pharmaceutically active ingredient relative to fill composition viscosity for dosage units. The process is particularly useful in the preparation of soft gelatin capsules containing ibuprofen, naproxen, indomethacin, and acetaminophen, as the pharmaceutically active ingredient. As a result of the process, lesser quantities of composition ingredients other than the pharmaceutically active ingredient are needed to accomplish the same therapeutically effective dosage, thereby significantly increasing the concentration of the pharmaceutically active ingredient resulting in either a reduction in overall fill volume and dosage unit size or an increase in concentration of pharmaceutically active ingredient per dosage form.

Cette invention concerne un procédé permettant d'accroître, par unité posologique, la concentration d'un principe actif pharmaceutiquement par rapport à la viscosité de l'excipient. Ce procédé convient particulièrement bien pour la préparation de capsules gélatineuses molles renfermant comme principe actif de l'ibuprofène, du naxoprène, de l'indométhacine et de l'acétominophène. Il est ainsi possible de réduire les quantités d'éléments constitutifs autre que le principe actif tout en obtenant la même dose thérapeutiquement efficace, ce qui permet d'augmenter sensiblement la concentration du principe actif. Par voie de conséquence, on peut soit réduire le volume global d'excipient et de l'unité posologique, soit accroître la concentration du principe actif par forme galénique.

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